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4238334 
Journal Article 
Influence of exposure to perfluoroalkyl substances (PFASs) on the Korean general population: 10-year trend and health effects 
Seo, SH; Son, MH; Choi, SD; Lee, DH; Chang, YS 
2018 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
113 
149-161 
English 
This study demonstrated the 10-year trend of 13 perfluoroalkyl substances (PFASs) serum levels among 786 adults living in Seoul, Korea. PFAS levels gradually increased from 2006 to 2013, decreasing thereafter. We found that PFAS levels were higher in male than in female participants and were positively correlated with age. PFASs were not significantly correlated with body mass index, although we observed positive correlations with total cholesterol, low-density lipoprotein cholesterol, and triglycerides and negative correlations with high-density lipoprotein cholesterol. Uric acid and free thyroxine (fT4) also showed positive correlations with major congeners while correlations between thyroid stimulating hormone and PFASs were inconsistent. We demonstrated significant correlations between fT4 and perfluorononanoic acid (PFNA), perfluorohexane sulfonate (PFHxS), and perfluorodecanoic acid (PFDA). There were significant differences in PFHxS and perfluorododecanoic acid (PFDoDA) levels between participants with and without diabetes. Furthermore, principal component analysis suggested possible differences in disease manifestation based on the congener distribution of PFASs. This study is the first study of temporal trends of 13 PFAS congeners in serum samples obtained from the Korean general population; it is currently longest and largest scale study of this type. 
PFASs; Serum; Temporal trend; Health effects; Korea 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          PubMed
          Web of Science
          Other Sources
               TEDX
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     Perfluorododecanoic acid
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          Other Sources
               PFAS TOX Database
     Screened Studies
          Included
               Include (TIAB)
          Excluded
               Exclude (Full Text)
     Perfluorododecanoic acid
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
          Other sources
               Reference list review of included studies
               PFAS TOX Database
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     Ammonium perfluorooctanoate
     Perfluorinated compounds
     Perfluorodecanoic acid
     Perfluorohexanesulfonic acid
     Perfluorononanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Included
                    Include (TIAB)
               Excluded
                    Exclude (Full Text)
     Ammonium perfluorooctanoate
     Perfluorodecanoate
     Perfluorodecanoic acid
     Perfluorododecanoic acid
     Perfluorohexane
     Perfluorohexanesulfonate
     Perfluorohexanesulfonic acid
     Perfluorononanoic acid
     Perfluorooctanoate
     Sodium perfluorohexanesulfonate
     Perfluorooctanoic acid
• PFBS
     Included
          Met PECO Criteria
               Human
• PFDA
     Literature Search
          Pubmed
          Other
               Published PFAS SEMs
     Literature Search Update 5/2019
          PubMed
     Scopus: April 2021
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effect studies
     June 2022 Pelch Database
     Literature Searches (through April 2023 update and post-public comment/peer review)
          Title & Abstract Screening
               Full Text Screening
                    Studies Meeting PECO
                         Human health effects studies
• PFHxA
     Literature Search
          Pubmed
          WOS
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effects studies
     Results pulled from Pelch database May 2022
     HAWC
• PFHxS
     Database searches
          Pubmed
          Toxline
          Scopus
          Pelch PFAS SEM
     Inclusion
          TiAb
          Full Text
               Human Study
• PFNA
     Litsearch Update 2017-2018
          PFAS Untag
     PFNA Literature Search pre-2019
          WOS
     Literature Search
          Pubmed
          Toxline
          WOS
     PFNA May 2019 Update
          Pubmed
          Toxnet
          Web of Science
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effects studies
     June 2022 Pelch Database
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search Update (2013-2019)
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers