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3856484 
Journal Article 
New approach for assessing human perfluoroalkyl exposure via hair 
Alves, A; Jacobs, G; Vanermen, G; Covaci, A; Voorspoels, S 
2015 
Yes 
Talanta
ISSN: 0039-9140
EISSN: 1873-3573 
144 
574-583 
English 
In the recent years hair has been increasingly used as alternative matrix in human biomonitoring (HBM) of environmental pollutants. Sampling advantages and time integration of exposure assessment seems the most attractive features of hair matrix. In the current study, a novel miniaturized method was developed and validated for measuring 15 perfluoroalkyl substances (PFAS), including perfluoro n-butanoic acid (PFBA), perfluoro n-pentanoic acid (PFPeA), perfluoro n-hexanoic acid (PFHxA), perfluoro n-heptanoic acid (PFHpA), perfluor n-octanoic acid (PFOA), perfluoro n-nonanoic acid (PFNA), perfluoro tetradecanoic acid (PFTeDA), perfluorobutane sulfonic acid (PFBS), perfluoro pentane sulfonic acid (PFPeS), perfluorohexane sulfonic acid (PFHxS), perfluoroheptane sulfonic acid (PFHpS), perfluorooctane sulfonic acid (PFOS), perfluorononane sulfonic acid (PFNS), perfluorodecane sulfonic acid (PFDS) and perfluorododecane sulfonic acid (PFDoS) in human hair by liquid chromatography tandem mass spectrometry (LC-MS/MS). After extraction using ethyl acetate, dispersive ENVI-Carb was used for clean-up. Good intra- and inter-day precision for low (LQ 5 ng/g hair) and high spike (HQ 15n g/g) levels were achieved (in general RSD <10%). The accuracy was assessed using recoveries (%), which ranged between 68-118% (LQ) and 70-121% (HQ). The instrumental limit of detection (LODi) and limit of quantification (LOQi) were between 1-4 pg/g hair and 3-13 pg/g hair, respectively. The method limit of quantification (LOQm) ranged between 6 and 301 pg/g hair. The PFAS levels were measured in 30 human hair samples indicating that the levels are low (14-1534 pg/g hair). Some PFAS were not present in any hair sample (e.g. PFHpA, PFTeDA, PFNA, PFPeS, PFHpS, PFOS and PFNS), while other PFAS were frequently detected (PFBA, PFPeA, PFHxA, PFOA, PFBS, PFHxS, PFOS, PFDS and PFDoS) in human hair. Although levels in general were low, there is evidence of higher human exposure to some analytes, such as PFBA, PFPeA, PFHxA, PFOA, PFBS, PFHxS, and PFDoS. The current study shows that hair is a suitable alternative non-invasive matrix for exposure assessment of PFAS. 
Perfluoroalkyl substances; Human biomoritoring; Hair; LC-ESI-MS/MS 
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFBS (375-73-5)
          Literature Search
               Pubmed
               WOS
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     PFHpA (375-85-9)
          Literature Search
               Pubmed
               WOS
     PFHxA (307-24-4)
          Literature Search
               Pubmed
               WOS
     PFPeA (2706-90-3)
          Literature Search
               Pubmed
               WOS
     PFBA (375-22-4)
          Literature Search
               Pubmed
               WOS
     PFDS (335-77-3)
          Literature Search
               Pubmed
               WOS
     PFNS (68259-12-1)
          Literature Search
               Pubmed
               WOS
     PFHpS (375-92-8)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFPeS (2706-91-4)
          Literature Search
               Pubmed
               WOS
• PFBA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFBS
          Pubmed
          WOS
          Excluded/Not on Topic
     Search
          PubMed
          WOS
     Excluded
          WOS
• PFDS
     Literature Search
          Pubmed
          WOS
• PFHpA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFHpS
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFHxA
     Literature Search
          Pubmed
          WOS
     Literature Search: February 2018 Update
          Term Set 2: Initial Search
               WoS
     Screening Results
          Excluded/Not on Topic
     Title and Abstract Screening
          Excluded
               Not relevant to PECO
     Literature Search
          Pubmed
          WOS
• PFHxS
     Literature Search
          PubMed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFNA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     PFNA Literature Search pre-2019
          WOS
          Pubmed
• PFNS
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFPeA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFPeS
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic