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3859814 
Journal Article 
ADONA and perfluoroalkylated substances in plasma samples of German blood donors living in South Germany 
Fromme, H; Wöckner, M; Roscher, E; Völkel, W 
2017 
Yes 
International Journal of Hygiene and Environmental Health
ISSN: 1438-4639
EISSN: 1618-131X 
220 
2 Pt B 
455-460 
English 
Perfluorinated compounds are fully fluorinated anthropogenic substances that have been used in various products, applications, and industrial processes. Due to their persistence and toxic effects, some of them are restricted, and therefore replacement products have been developed. The aim of the study was to quantify the body burden of different perfluorinated substances in two adult populations living close to or about 80km apart from a former perfluorooctanoate (PFOA) production plant who are exposed via drinking water, and in a control population. In this plant, the replacement emulsifier 3H-perfluoro-3-[(3-methoxy-propoxy)propanoic acid] (ADONA) has been used in the production of fluoropolymers since 2008. We quantified 7 perfluorinated compounds and ADONA in a total of 396 plasma samples collected at different time points. With regard to samples collected in 2015 or 2016, the highest 95th percentile levels were 13.5μg/l for perfluorooctane sulfonate (PFOS), 3.0μg/l for perfluorononanoate (PFNA), and 1.5μg/l for perfluorohexane sulfonate (PFHxS). For PFOA, the highest 95th percentile was found at the site close to the facility (85.5μg/l), while in the control region the value was 2.4μg/l. Overall, the concentration of PFOA and PFOS declined over time in all study regions. ADONA was detected only in few samples slightly above the limit of quantification (0.2μg/l). While health risks related to ADONA are unlikely under the present exposure situation, the exposure to PFOA via tap water should be reduced markedly, especially for the population living close to the plant. 
PFAS
• ADONA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     ADONA (919005-14-4)
          Literature Search
               Pubmed
               WOS
• PFHxS
     Literature Search
          PubMed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFNA
     Literature Search
          Pubmed
          Toxline
          WOS
     Screening Results
          Excluded/Not on Topic
     PFNA May 2019 Update
          Web of Science
          Pubmed
          Toxnet
     PFNA Literature Search pre-2019
          WOS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS