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3858476 
Journal Article 
Perfluorinated alkyl substances in Spanish adults: Geographical distribution and determinants of exposure 
Bartolomé, M; Gallego-Picó, A; Cutanda, F; Huetos, O; Esteban, M; Pérez-Gómez, B; Bioambient.es; Castaño, A 
2017 
Yes 
Science of the Total Environment
ISSN: 0048-9697
EISSN: 1879-1026 
603-604 
352-360 
English 
Per- and polyfluoroalkyl substances (PFAS) are widely found in humans and the environment. Their persistence, bioaccumulation and toxicity make them a source of increasing public health concern. In this study, we analyzed the concentrations and geographical distribution of six PFAS in the serum of 755 Spanish adults aged 18-65. The geometric mean concentrations (and P95 values) for PFOS (perfluoroctane sulfonate), PFOA (perfluorooctanoic acid), PFHxS (perfluorohexane sulfonate), PFNA (perfluorononanoic acid) and PFDA (perfluorodecanoic acid) were 7.67 (19.3), 1.99 (5.48), 0.91 (2.84), 0.96 (2.44) and 0.42 (0.99) μg/L, respectively. N-Methylperfluorooctane sulfonamide (N-MeFOSAA) was detected in only 3.3% of samples. Residents in northeast (Catalonia) and northwest of Spain (Galicia) were found to have the highest serum values, whereas residents in the Canary Islands had the lowest values for almost all PFAS. Men presented higher levels than women, and we confirm that lactation (breastfeeding) contributes to a reduced body burden for all PFAS in women. Our data provide new information on exposure to PFAS in a national cross section sample of Spanish adults, thus providing a proxy for reference values for the Spanish population and forming the base for following temporal trends in the future. 
Exposure Spanish adults; Human biomonitoring; Human serum samples; Perfluorinated alkyl substances 
• NMeFOSAA
     Literature Search
          Pubmed
     Screening Results
          Susceptible populations
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFDA (335-76-2)
          Literature Search
               Pubmed
     PFNA (375-95-1)
          Literature Search
               Pubmed
     PFHxS (355-46-4)
          Literature search
               Pubmed
     NMeFOSAA (2355-31-9)
          Literature Search
               Pubmed
• PFDA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Susceptible populations
     Title and Abstract Screening
          Full Text Screening
          Tagged as Supplemental
               Exposure assessment or qualitative exposure only
• PFHxS
     Literature Search
          PubMed
          Toxline
          WOS
     Screening Results
          Excluded/Not on Topic
• PFNA
     Literature Search
          Pubmed
          Toxline
          WOS
     Screening Results
          Susceptible populations
     PFNA May 2019 Update
          Web of Science
          Pubmed
          Toxnet
     PFNA Literature Search pre-2019
          WOS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Susceptible populations
     Literature Search Update (2013-2019)
          PubMed
          WOS