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2915548 
Journal Article 
Exposure to select phthalates and phenols through use of personal care products among Californian adults and their children 
Philippat, C; Bennett, D; Calafat, AM; Picciotto, IH 
2015 
Yes 
Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 
Environ Res. 2015, Jul; 140:369-76. [Environmental research] 
140 
369-376 
English 
INTRODUCTION: Certain phenols and phthalates are used in many consumer products including personal care products (PCPs).

AIMS: We aimed to study the associations between the use of PCPs and urinary concentrations of biomarkers of select phenols and phthalates among Californian adults and their children. As an additional aim we compared phenols and phthalate metabolites concentrations measured in adults and children urine samples collected the same day.

METHODS: Our study relied on a subsample of 90 adult-child pairs participating in the Study of Use of Products and Exposure Related Behavior (SUPERB). Each adult and child provided one to two urine samples in which we measured concentrations of selected phenols and phthalate metabolites. We computed Spearman correlation coefficients to compare concentrations measured in adults and children urine samples collected the same day. We used adjusted linear and Tobit regression models to study the associations between the use of PCPs in the past 24h and biomarker concentrations.

RESULTS: Benzophenone-3 and parabens concentrations were higher in adults compared to their children. Conversely children had higher mono-n-butyl phthalate and mono-isobutyl phthalate concentrations. No significant difference was observed for the other compounds. The total number of different PCPs used was positively associated with urinary concentrations of methyl, propyl and butyl parabens and the main metabolite of diethyl phthalate in adults. Among children, the use of a few specific products including liquid soap, hair care products and sunscreen was positively associated with urinary concentrations of some phenols or phthalate metabolites.

DISCUSSION: These results strengthen the body of evidence suggesting that use of PCPs is an important source of exposure to parabens and diethyl phthalate in adults and provide data on exposure to selected phenols and phthalates through use of PCPs in children. 
Endocrine disruptors; Parabens; Personal care products; Phenols; Phthalates; Temporal variability 
IRIS
• Dibutyl Phthalate (DBP)
     Database Searches
          Litsearch March 2015 - June 2015
               Pubmed
          LitSearch Jul 2016 - Jan 2017
               Prior search overlap
               PubMed
               WoS
     Excluded: No Primary Data on Health Effects
          Exposure levels
     Litsearch June 2015 - Jan 2016
          Web of Science
• Diethyl phthalate (DEP)
     Database searches
          Jun 2015 update
               Pubmed
          Jan 2020 update
               PubMed
               Web of Science
     Excluded: No Primary Data on Health Effects
          Exposure levels
• Diisobutyl Phthalate (DIBP) Final
     Database Searches
          December 2015 Update
               New for This Search
               Pubmed
               Web of Science
          June 2016 Update
               Pubmed
               Toxline
               Web of Science
          January 2017 Update
          July 2017 Update
     No Primary Data on Toxic Effects
          Exposure levels
• Phthalates – Targeted Search for Epidemiological Studies
     Source – all searches
          Pubmed
          WOS
     Excluded
     Source – Dec 2015 Update (Private)
          Pubmed
          WOS
     Source - Jun 2016 Update (Private)
          WOS