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3858487 
Journal Article 
Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma 
Mamsen, LS; Jönsson, BAG; Lindh, CH; Olesen, RH; Larsen, A; Ernst, E; Kelsey, TW; Andersen, CY 
2017 
Yes 
Science of the Total Environment
ISSN: 0048-9697
EISSN: 1879-1026 
596-597 
97-105 
English 
BACKGROUND: Perfluoroalkyl substances (PFASs) are bio-accumulative pollutants, and prenatal exposure to PFASs is believed to impact human foetal development and may have long-term adverse health effects later in life. Additionally, maternal cigarette smoking may be associated with PFAS levels. Foetal exposure has previously been estimated from umbilical cord plasma, but the actual concentration in foetal organs has never been measured.

OBJECTIVES: The concentrations of 5 PFASs and cotinine - the primary metabolite of nicotine - were measured in human foetuses, placentas, and maternal plasma to evaluate to what extent these compounds were transferred from mother to foetus and to determine if the PFAS concentrations were associated with maternal cigarette smoking.

METHODS: Thirty-nine Danish women who underwent legal termination of pregnancy before gestational week 12 were included; 24 maternal blood samples were obtained together with 34 placental samples and 108 foetal organs. PFASs and cotinine were assayed by liquid chromatography/triple quadrupole mass spectrometry.

RESULTS: In foetal organs, the average concentrations of perfluorooctanesulphonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDa), and perfluorodecanoic acid (PFDA) were 0.6ng/g, 0.2ng/g, 0.1ng/g, 0.1ng/g, and 0.1ng/g, respectively. A significant positive correlation was found between the exposure duration, defined as foetal age, and foetal to maternal ratio for all five PFASs and cotinine. Smokers presented 99ng/g cotinine in plasma, 108ng/g in placenta, and 61ng/g in foetal organs. No correlation between the maternal cotinine concentrations and PFAS concentrations was found.

CONCLUSIONS: PFASs were transferred from mother to foetus, however, with different efficiencies. The concentrations of PFOS, PFOA, PFNA, PFUnDA, and PFDA in foetal organs were much lower than the maternal concentrations. Furthermore, a significant correlation between the exposure duration and all of the evaluated PFASs was found. The health-compromising concentrations of these substances during foetal development are unknown. 
Prenatal exposure; Perfluorinated compounds; Cigarette smoke; Maternal plasma; Placenta 
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
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               Pubmed
               WOS
     PFUnA (2058-94-8)
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     PFDA (335-76-2)
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• PFDA
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     Title and Abstract Screening
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               Studies Considered Further
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          Tagged as Supplemental
               ADME
• PFHxA
     Title and Abstract Screening
          Full Text Screening
               Studies Considered Further
                    Human health effects studies
     Literature Search
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• PFNA
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          Pubmed
          Toxline
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     Screening Results
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               ADME
     PFNA May 2019 Update
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          Toxnet
     PFNA Literature Search pre-2019
          WOS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Toxicokinetic studies
               ADME
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFUnA
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          Pubmed
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     Screening Results
          Toxicokinetic studies
               ADME
          Susceptible populations