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4174662 
Journal Article 
Investigation of the best approach for assessing human exposure to poly- and perfluoroalkyl substances through indoor air 
Padilla-Sánchez, JA; Papadopoulou, E; Poothong, S; Haug, LS 
2017 
Yes 
Environmental Science and Technology
ISSN: 0013-936X
EISSN: 1520-5851 
51 
21 
12836-12843 
English 
is supplemented by 4442171 : Supplemental materials
Per- and polyfluoroalkyl substances (PFASs), including fluorotelomer alcohols (FTOHs), perfluoroalkyl sulfonamidoethanols (FOSEs), and perfluoroalkyl sulfonamides (FOSAs), were assessed in 61 residential indoor air and 15 personal air samples collected in Oslo area, Norway. FTOHs were detected in all samples, and the median concentrations in residential indoor air were 2970, 10400, and 3120 pg m-3 for 6:2, 8:2, and 10:2 FTOH, respectively. This is similar to or higher than previously reported in studies from the same geographical area and worldwide. FOSEs and FOSAs were detected in 49-70% and 7-13% of the residential indoor air samples, respectively. The median FTOH concentrations observed in personal air were 1970, 7170, and 1590 pg m-3 for 6:2, 8:2, and 10:2 FTOH, respectively, which is 30 to 50% lower than the median concentrations in residential indoor air. No FOSEs or FOSAs were detected above the method detection limit (MDL) in the personal air samples. Intakes of perfluorohexanoate (PFHxA), perfluoroheptanoate (PFHpA), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA), perfluoroundecanoate (PFUnDA), and perfluorooctyl sulfonate (PFOS) through inhalation and biotransformation of PFAS precursors in air were estimated. Median intakes of 1.7, 0.17, 5.7, 0.57, 1.8, 0.18, and 2.3 pg kg bw-1 day-1 were obtained in residential indoor air, while 1.0, 0.10, 3.3, 0.33, 0.88, and 0.09 pg kg bw-1 day-1 were found in personal air for PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, and PFOS, respectively. The median PFOA intakes from residential indoor air (5.7 pg kg bw-1 day-1) and personal air (3.3 pg kg bw-1 day-1) were both around 5 orders of magnitude lower than the tolerable daily intake (TDI) reported by the European Food Safety Authority (EFSA). 
Environmental Studies; Human exposure; Alcohol; Indoor air quality; Food safety; Indoor environments; Respiration; Indoor air pollution; Inhalation; Biotransformation; Alcohols; Residential areas; Sulfonamides; Intakes 
• PFDA
     Literature Search
          Pubmed
          WOS
     Title and Abstract Screening
          Excluded
• PFHpA
     Literature Search Update 2017-2019
          PubMed
          WOS
• PFHxA
     Literature Search: February 2018 Update
          PubMed
          WoS
          Term Set 2: Initial Search
               PubMed
               WoS
     Literature Search
          Pubmed
          WOS
     Title and Abstract Screening
          Excluded
               Not relevant to PECO
• PFNA
     PFNA Literature Search pre-2019
          WOS
     Literature Search
          Pubmed
          WOS
     PFNA May 2019 Update
          Pubmed
          Toxnet
          Web of Science
     Title and Abstract Screening
          Full Text Screening
          Tagged as Supplemental
               Exposure assessment or qualitative exposure only
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search Update (2013-2019)
          PubMed
          WOS