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3858507 
Journal Article 
Temporal trends of PFSAs, PFCAs and selected precursors in Australian serum from 2002 to 2013 
Eriksson, U; Mueller, JF; Toms, LL; Hobson, P; Kärrman, A 
2017 
Yes 
Environmental Pollution
ISSN: 0269-7491
EISSN: 1873-6424 
ELSEVIER SCI LTD 
OXFORD 
220 
Pt A 
168-177 
English 
is supplemented by 3981676 : Supplementary materials
Per- and polyfluoroalkyl substances (PFASs) are a family of compounds that includes numerous compound classes. To date, only a subset of these PFASs have been studied thoroughly in the general population. In this study, pooled serum samples from Australia collected in 2002-2013 were analyzed for PFASs according to gender and age (age categories of 0-4 years, 5-15 years, 16-30 years, 31-45 years, 46-60 years, and >60 years), in total 54 pooled samples and 4920 individuals. Compound classes included were perfluorocarboxylic acids (PFCAs), perfluorosulfonic acids (PFSAs), and two groups of PFCA precursor compounds; polyfluoroalkyl phosphate diesters (diPAPs), and fluorotelomer sulfonic acids (FTSAs). Several PFASs that were not reported in previous studies of Australian serum samples were found in this sample set including; diPAPs, FTSAs, perfluoropentane sulfonic acid (PFPeS), perfluoroheptane sulfonic acid (PFHpS), perfluoroheptane carboxylic acid (PFHpA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid (PFTrDA). Various temporal trends were observed with a significant reduction (p < 0.05) between 2002 and 2013 for 8:2 FTSA, perflurohexane sulfonic acid (PFHxS), PFHpS, PFOS, and perflurooctanoic acid (PFOA). Levels of longer-chained PFDA and PFUnDA started to decrease more recently, between 2006 and 2013, while PFDoDA increased during the same time period. Higher levels in younger age groups (0-4 and 5-15 years) compared to adults (>15 years) were found for 8:2 FTSA and PFHpA, while levels of PFHpS, PFOS, PFUnDA, PFDoDA and PFTrDA were higher in adult age groups compared to younger age groups. Gender-specific patterns were seen for PFOA, PFHxS, PFHpS and PFOS, where levels were lower in women. Changes in manufacturing processes were reflected in the temporal time trends, and differences in bioaccumulation potential between homologues could be associated with age trends. Our results emphasize the importance of including emerging classes of PFASs in biomonitoring studies. 
diPAPs; FTSAs; Serum; Temporal trend; PFAS 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          PubMed
          Web of Science
     Screened Studies
          Supplemental
     Perfluorododecanoic acid
     Perfluoropentanesulfonic acid
• Expanded PFAS SEM (formerly PFAS 430)
     Perfluorododecanoic acid
     Perfluoropentanesulfonate
• FtS 8:2
     Literature Search
          Pubmed
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     Screening Results
          Susceptible populations
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFDoA (307-55-1)
          Literature Search
               Pubmed
               WOS
     PFUnA (2058-94-8)
          Literature Search
               Pubmed
               WOS
     PFDA (335-76-2)
          Literature Search
               Pubmed
               WOS
     PFHpA (375-85-9)
          Literature Search
               Pubmed
               WOS
     PFHpS (375-92-8)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFPeS (2706-91-4)
          Literature Search
               Pubmed
               WOS
     FtS 8:2 (39108-34-4)
          Literature Search
               Pubmed
               WOS
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
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     Perfluorodecanoic acid
     Perfluoroheptanesulfonic acid
     Perfluoroheptanoic acid
     Perfluorohexanesulfonic acid
     Perfluorooctanesulfonic acid
     Perfluorooctanoic acid
     Perfluorotridecanoic acid
     Perfluoroundecanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     8:2 Fluorotelomer sulfonic acid
     Perflenapent
     Perfluorodecanoate
     Perfluorodecanoic acid
     Perfluorododecanoic acid
     Perfluoroheptane
     Perfluoroheptanesulfonic acid
     Perfluoroheptanoate
     Perfluoroheptanoic acid
     Perfluorohexadecanoic acid
     Perfluorohexanesulfonate
     Perfluorohexanesulfonic acid
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluoropentanesulfonate
     Perfluoropentanesulfonic acid
     Perfluorotridecanoate
     Perfluorotridecanoic acid
     Perfluoroundecanoate
     Perfluoroundecanoic acid
     Sodium perfluorohexanesulfonate
     3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecane-1-sulfonate
     Perfluorooctanoic acid
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          Scopus
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• PFNA
     Litsearch Update 2017-2018
          PFAS Untag
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     PFNA May 2019 Update
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• PFPeS
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          Pubmed
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• PFUnA
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          Pubmed
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OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
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     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS