US EPA

675441 

Journal Article 

Review 

Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans 

Swan, SH 

2008 

Yes 

Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 

108 

2 

177-184 

English 

18949837 

10.1016/j.envres.2008.08.007 

WOS:000260132400007 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-52949101044&doi=10.1016%2fj.envres.2008.08.007&partnerID=40&md5=0b8e4f1432bf6c479ec1a541aeb198d5
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is related to other part(s) 673501 Decrease in anogenital distance among male infants with prenatal phthalate exposure
is related to other part(s) 732858 Future families: Background contamination and human reproductive health
is related to other part(s) 804890 Future families: Background contamination and human reproductive health

After briefly discussing human exposure to phthalates-diesters of 1,2-benzenedicarboxylic acid (phthalic acid)-this article first presents recent findings from the Study for Future Families, a multi-center pregnancy study in which the human analog of the phthalate syndrome was first identified. This is one of an increasing no. of studies that have investigated human endpoints in relation to environmental exposure to these ubiquitous compds. This literature, which includes a range of human health endpoints following prenatal, neonatal, childhood, and adult exposures, is then summarized. At least one significant assocn. has been reported for urinary metabolites of di-Bu phthalate (DBP), butylbenzyl phthalate (BzBP), di-Et phthlate (DEP), and di-isononyl phthalate (DINP) and for three of the urinary metabolites of di(2-ethylhexyl) phthalate (DEHP). Many of the findings reported in humans-most of which have been in males-are consistent with the anti-androgenic action that has been demonstrated for several phthalates. Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes. 

Phthalates; Genital dysmorphology; Anogenital distance; Phthalate syndrome 

Workshop on Plastic World 

Erice, Italy 

August 19-24, 2006