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3856460 
Journal Article 
Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones 
Li, Y; Cheng, Y; Xie, Z; Zeng, F 
2017 
Yes 
Scientific Reports
EISSN: 2045-2322 
43380 
English 
In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, TGAb, and TMAb) were determined in 202 human serum samples of the general population of Guangdong, Guangxi and Hainan provinces in southern China. Σ8PFASs concentrations ranged from 0.85 to 24.3 ng/mL with a mean value of 4.66 ng/mL. The PFASs composition profiles of human serum samples nearly make no difference at different locations. A significant increase was observed for ∑8PFASs, PFOS, and PFHxS concentrations with age (p < 0.01). Gender-related differences were found; PFOS, PFHxS, PFBS, and PFOA levels were higher in males (p < 0.05), and the mean concentration of ∑8PFASs was 1.5 times greater in males (6.02 ng/mL) than in females (4.15 ng/mL). PFOS and ∑8PFASs were significantly negatively correlated with FT3 and FT4 and positively correlated with TSH while PFPeA and PFHxA were significantly positively correlated with TGAb and TMAb in all the samples. The opposite associations between FT3, TSH and PFOS, PFOA and PFHxS levels in hypothyroidism and hyperthyroidism group indicate that the PFOS, PFOA and PFHxS enhance the negative feedback mechanisms of the thyroid gland. 
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFBS (375-73-5)
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     PFHxA (307-24-4)
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     PFPeA (2706-90-3)
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               Pubmed
               WOS
     PFHxS (355-46-4)
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               Pubmed
               WOS
• PFBA
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          WOS
     Screening Results
          Human/Epi studies
• PFBS
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          WOS
          Human/Epi studies
     Search
          PubMed
          WOS
          WOS
• PFHxA
     Title and Abstract Screening
          Full Text Screening
               Studies Considered Further
                    Human health effects studies
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          Pubmed
          WOS
• PFHxS
     Literature Search
          PubMed
          WOS
     Screening Results
          Human/Epi studies
               Thyroid bioactivity
• PFNA
     PFNA May 2019 Update
          Toxnet
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Human/Epi studies
               Thyroid bioactivity
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFPeA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Human/Epi studies
               Thyroid bioactivity