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Technical Report 
EPA Report 
Supplemental guidance for assessing susceptibility from early-life exposure to carcinogens 
U.S. Environmental Protection Agency :: U.S. EPA 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
is a supplement to 086237 Guidelines for carcinogen risk assessment
In 1983, the National Academy of Sciences (NAS)/National Research Council (NRC) published its report entitled Risk Assessment in the Federal Government: Managing the Process. In that report, the NRC recommended that Federal regulatory agencies establish ""inference guidelines"" to promote consistency and technical quality in risk assessments and to ensure that the risk assessment process was maintained as a scientific effort separate from risk management. EPA responded to this recommendation by publishing a set of risk assessment guidelines in 1986, including the Guidelines for Carcinogen Risk Assessment (51 FR 33992, September 24, 1986).
EPA began revising the 1986 cancer guidelines in light of significant advances in our understanding of the processes of carcinogenesis and the modes of actions of disease at the cellular level. Revising the cancer guidelines is in keeping with EPA's original intent when it issued the first set of final risk assessment guidelines in 1986. The risk assessment guidelines were meant to be dynamic, flexible documents that would evolve to reflect the current state of the science and risk assessment practices. In keeping with this, EPA undertook an effort to revise the cancer guidelines as described below in the History and Chronology section. 
Risk; Risk Assessment; Carcinogens 
• Ammonia
     Literature Search – March 2012 (private)
     Literature Search Results
     Not Chemical Specific
          Guidance, notices
     Cited 2016
• Arsenic Hazard ID
• Arsenic (Inorganic)
     Cited in Volume 1
• Asbestos
• Benzo(a)pyrene (BaP)
• Biphenyl
     Cited References
• tert-Butanol
     Cited in Document
• n-Butanol
     • Cited 2016 Public Comment Draft
          Tox Review
• tert-Butanol
     Cited in Public Comment Draft – May 2016
          Toxicological Review
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• Chromium VI
     Cited in Document
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Ethylbenzene
• Hexabromocyclododecane (HBCD)
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
• RDX (121-82-4)
     Cited 2015 (private)
• Tetrachloroethylene (Perc) (Final, 2012)
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
• Trimethylbenzenes (Interagency Science Discussion Draft)
• Trimethylbenzenes (TMB)
     Considered Studies
     Cited Studies
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Vanadium Pentoxide (Draft, 2011)
• ISA-Lead (2013 Final Project Page)
• ISA-Ozone (2013 Final Project Page)
• ISA-PM (2009 Final Project Page)
• ISA-PM (current)
• Exposure Factors Handbook (Post 2011)
     Chapter 1
     Chapter 6
• Nanoscale Carbon
• Nanoscale Silver
• Ramazzini Institute