These guidelines revise and replace the U.S. Environmental Protection Agency’s (EPA’s,
or the Agency’s) Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992,
September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a;
see U.S. EPA 2001b). They provide EPA staff with guidance for developing and using risk
assessments. They also provide basic information to the public about the Agency's risk
assessment methods.