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6324329 
Technical Report 
EPA Report 
Guidelines for carcinogen risk assessment 
U.S. Environmental Protection Agency :: U.S. EPA 
2005 
Yes 
U.S. Environmental Protection Agency 
Washington, DC 
EPA630P03001F 
166 
English 
is supplemented by 088823 Supplemental guidance for assessing susceptibility from early-life exposure to carcinogens
These guidelines revise and replace the U.S. Environmental Protection Agency’s (EPA’s,
or the Agency’s) Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992,
September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a;
see U.S. EPA 2001b). They provide EPA staff with guidance for developing and using risk
assessments. They also provide basic information to the public about the Agency's risk
assessment methods. 
PB2005105899 
• Ammonia
     Literature Search – March 2012 (private)
     Literature Search Results
     Not Chemical Specific
          Guidance, notices
     Cited 2016
          ToxReview
• Arsenic Hazard ID
• Arsenic (Inorganic)
     Cited in Volume 1
• Asbestos
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
          Carcinogenicity
• Biphenyl
     Considered
     Cited References
          Other studies
               Dose-response assessment
          Guidance
• tert-Butanol
     Cited in Document
• n-Butanol
     • Cited 2016 Public Comment Draft
          Tox Review
• tert-Butanol
     Cited in Public Comment Draft – May 2016
          Toxicological Review
          Supplemental Materials
• Chloroform Combined (current)
     Chloroform (original)
     Chloroform (current)
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• Chromium VI
     Cited in Document
     Not in Lit Search
• Cobalt
     Cobalt IAP/Protocol
          Exclude
     References from Other Sources
          CalEPA (2020)
          PPRTV
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• ETBE
     Cited in Document
     Not in Lit Search
• Ethylbenzene
     Protocol template references
• Formaldehyde
     Prior to 2013 Search
     UR Cancer MOA
     Genotoxicity
          Cited
     Cited in text
     Retroactive RIS import
          Pre2013
               Formaldehyde IRIS 2011
                    Old references
                    Standard IRIS references
• Hexabromocyclododecane (HBCD)
• Inorganic Mercury Salts (2)
     Litcite References – Protocol
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Ramazzini
• Methylmercury
     Cited in Document
     Protocol Assessment
• Naphthalene
• Nitrate/Nitrite
     Other resources cited in assessment
• PCBs
     Cited (Nov 2012)
     IRIS assessment protocol template
• RDX (121-82-4)
     Cited 2015 (private)
• Tetrachloroethylene (Perc) (Final, 2012)
     Hazard
          Genotox
          Susceptibility
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Hazard
     Cancer Epi
     Genotox
     Kidney
     Liver
     Respiratory
     Susceptibility
     Dose-Response
     Non-Cancer
     Cancer
     Liver Issues
• Trimethylbenzenes (Interagency Science Discussion Draft)
     Primary Literature Search
     Primary Literature Search- Considered
          Cited
     Cited August 2016
          Cited Toxicological Review
          Cited Supplemental Information
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Uranium Toxicological Review
     Additional Strategies
• Vanadium Compounds - Problem Formulation
     Manual review of existing IRIS and PPRTV assessments
          IRIS 2011/2014
          PPRTV 2008
          PPRTV 2009
     Combined data set
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
     Cited in IAP
     Cited in protocol
• Vanadium Inhalation
     Combined Dataset
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
     Supporting Documents
     Cited in IAP
     Cited in Protocol
• Vanadium Pentoxide (Draft, 2011)
NAAQS
• ISA-Lead (2013 Final Project Page)
     Cited
          2nd Draft
          3rd Draft
          Final
• ISA-NOx (2016)
     Cited
          1st Draft
          2nd Draft
          Final
          Final Cited
• ISA-Ozone (2013 Final Project Page)
     Considered
     Cited
          1st Draft
          2nd Draft
          3rd Draft
          Final
     Health Effects
• ISA-Ozone (2020 Final Project Page)
     Full-Text Screening Included
          References from Other Sources
     Included in ISA First Draft
          Appendix 3
          Appendix 4
          Appendix 5
          Appendix 6
          Appendix 7
     Included in ISA Final Draft
          Appendix 3
          Appendix 4
          Appendix 5
          Appendix 6
          Appendix 7
• ISA-PM (2009 Final Project Page)
     2009 Final
• ISA-PM (2019)
     1st Draft
          P-ES-A
     Final ISA
          P-ES-A
• ISA-SOx
     Considered
     Cited in First ERD Nov2015
     Cited Second ERD Dec2016
     Cited in Final ISA Dec2017
          Chapter 5 – Health
OPPT REs
• OPPT_1,4-Dioxane_A. Summary
     Cited in TSCA RE related document
• OPPT_1,4-Dioxane_C. Engineering
     Data screening total
          Screening: Excluded
• OPPT_1,4-Dioxane_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_1-Bromopropane (1-BP)_A. Summary
     Cited in TSCA RE related document
• OPPT_Carbon Tetrachloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Secondary source/ Review
               Cited in IRIS document or IRIS HERO page
• OPPT_Methylene Chloride_A. Summary
     Cited in TSCA RE related document
• OPPT_Methylene Chloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_A. Summary
     Cited in TSCA RE related document
• OPPT_Perchloroethylene (Perc)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_A. Summary
     Cited in TSCA RE related document
• OPPT_Trichloroethylene (TCE)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          Off topic
• PFBA
     Protocol References
     Supplemental References
• PFBS
     Included
          Supporting References
• PFDA
• PFHxA
     Title and Abstract Screening
          Tagged as Supplemental
               Background/Exposure References
     HAWC
• PFHxS
     Background References
• PFNA
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers
• Exposure Factors Handbook (Post 2011)
     Chapter 1
     Chapter 6
     Glossary
• Mouse Lung Tumor Workshop 2014
• Nanoscale Carbon
     All References Cited
     External Review Draft
          Impacts
     Peer Reviewed Draft
          Impacts
               Lower Priority Areas: Appendices G and H
     Final Case Study
          Product Life Cycle
               Lower Priority Areas: Appendices G and H
          Transport & Fate
               Lower Priority Areas: Appendices G and H
          Exposure, Uptake, and Dose
               Lower Priority Areas: Appendices G and H
          Impacts
               Lower Priority Areas: Appendices G and H
• Nanoscale Silver
     External Review Draft
     Final Case Study
          Exposure, Uptake and Dose
          Effects
• Naphthalene (2021 Evidence mapping publication)
• Project 9 – Soil and Dust Ingestion
     Cited October 2016
          Carcinogenicity Assessment- Cited
          Supplemental Information - Cited
• Ramazzini Institute